Ryan Moreira

The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.

This study identifies a conserved FHAFRF-motif in precursor peptides of MNIO-encoding BGCs and demonstrates that MNIO and B12-rSAM enzymes catalyze ortho-hydroxylation and crosslinking of phenylalanine residues to form macrocyclic peptides.

The paper characterizes six gut-derived nisin-like lantibiotics, evaluates their antimicrobial activity against pathogens and commensals, and identifies key residues affecting their activity.

This paper identifies bibacillin 1, a two-component lantibiotic from Bacillus thuringiensis, showing cooperative bactericidal activity and distinct mechanism of action compared to other lantibiotics.