Matthias Farlik

This study shows JAK1/2 inhibition reduces pathogenic immune responses and restores tissue integrity in chronic skin inflammation by shifting immunity toward IL-17 responses.

This study identifies a conserved chromatin-driven maturation checkpoint in macrophages that occurs independently of tissue specialization and enhances innate immune responsiveness.

This paper introduces a 3D co-culture model of bone sarcoma metastasis in the lung and identifies a contact-dependent epithelial remodeling response with potential therapeutic targets.

This study investigates the role of Mtor/Rptor in cortical development, finding that its loss causes microcephaly through tissue-wide effects, while cell-autonomous Rptor function is critical for postnatal neuron survival in a cell-type-specific manner.

This study shows that EGFR protects hair follicle stem cells from immune-mediated damage by maintaining JAK-STAT1-sensitive immune privilege, and its disruption leads to scarring hair loss, which can be reversed by JAK1/2 inhibition.

The paper maps DNA methylation in 580 animal species, revealing conserved and evolving patterns across vertebrates and invertebrates.

The paper analyzes sensory cell types in Platynereis dumerilii to explore the evolutionary relationship between photo- and mechanoreceptors, finding that r-Opsin1 modulates mechanosensation through light-dependent mechanisms.

The paper identifies novel imprinted genes in mouse blastocysts and shows that their expression is mostly independent of DNA methylation but associated with H3K27me3 marks.