Lance L. Munn

This study identifies sex-biased mechanisms of immune aging in males, showing lymph node contraction reduces naive CD8 T cell availability and compromises cancer antigen recognition, with potential therapeutic interventions.

This study develops immortalized smooth muscle cells to support stable in vitro vasculogenesis, enabling long-term vascularized tumor models for functional studies and drug screening.

This paper develops a 3D tumor microenvironment model to predict CAR-T therapy outcomes in solid tumors, finding that collagen density and metabolic competition are key determinants of efficacy.

The paper shows that sustained cell volume expansion in melanoma primes cells to develop drug tolerance while increasing susceptibility to CD8+ T cell killing.

The paper introduces a hybrid model combining lattice Boltzmann and finite difference methods to efficiently simulate fluid transport in porous media with moving boundaries, showing a fourfold speed improvement.

This study shows that breast tumors impair antigen presentation in local lymph nodes, which can be overcome by delivering IL1β or adjuvants to distant lymph nodes, improving anti-cancer immune responses.

This paper develops a PBPK model to optimize cancer vaccine design by simulating antigen transport and immune responses across organs.

The paper develops a physiologically based pharmacokinetic model to simulate CAR-T cell dynamics in solid tumors, showing vascular normalization improves efficacy and reduces required CAR-T doses.

This study uses an agent-based model to simulate T-cell interactions with tumors and identifies parameter optimizations that enhance tumor clearance.

This study shows oncolytic virus therapy primarily elicits anti-virus T cell responses rather than anti-cancer responses, explaining limited clinical efficacy in metastatic disease.

This paper develops a multiresolution imaging and analysis approach to quantify lymphatic pumping dynamics, improving measurement reliability across species and conditions.

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.