Grace D. O’Connell

This study examines the effects of 28 days of spaceflight on the murine lumbar spine and proximal tibia, finding no significant changes in vertebral bone microarchitecture or intervertebral disc properties, but significant bone loss in the tibia.

This paper identifies a pivot-clip mechanism that enhances 5β1 integrin-fibronectin binding dynamics, reinforcing cell adhesion through conformational changes induced by mechanical forces.