Femke M. S. de Vrij

This study benchmarks clustering methods for high-dimensional spike time-window data from MEAs, finding that PCA with k-means and Euclidean distance performs best.

The paper shows that SYNGAP1 splice-switching therapy may be ineffective in mature neurons due to reduced A3SS transcript abundance.

This paper introduces a method to generate adherent cortical organoids in a multiwell format, showing reproducible 3D cortical layer formation and potential for drug discovery and disease modeling.

This study shows that Influenza A Virus infection impairs neuronal activity in human iPSC-derived neural co-cultures without causing cell death or efficient virus replication.

This study investigates how EV-D68 and EV-A71 affect neural activity in human iPSC-derived neural co-cultures, finding virus-specific disruptions without correlation to replication efficiency.

The paper identifies a novel pathway where astrocytes clear pre-synaptic autophagosomes from neurons through a cholesterol-dependent endocytosis process without requiring direct cell contact or retrograde transport.

This study develops a method to differentiate human pluripotent stem cells into functional astrocytes in 28 days, validated by marker expression and network activity support.

This study investigates neuronal hyperactivity in human cerebral organoids derived from individuals with grey matter heterotopia, identifying functional and structural changes linked to the condition.

The paper identifies miRNAs selectively loaded into extracellular vesicles from healthy human astrocytes and links them to neurodevelopmental disorders.

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

This study identifies 24 genetic loci associated with facial shape variation in humans through GWAS and confirms 13 of them in a multi-ethnic cohort.