Caitlin L. Rowe

This study investigates the functional differences between MTX1 and MTX3, showing that their loss leads to distinct mitochondrial phenotypes and that both depend on MTX2 for stability.

This study identifies heme biosynthesis as a selective dependency in AML, showing that its inhibition triggers cuproptosis via copper accumulation and reveals synthetic lethal pathways for therapeutic strategies.

This study replaces MCL-1 with other anti-apoptotic proteins in mice to determine the relative importance of MCL-1's anti-apoptotic versus non-apoptotic functions in development and physiology.