Paul S. Frenette

This study identifies microbiome-immune-pathophysiology axes in sickle cell disease by analyzing bacterial and viral gut microbiome alterations.

This study challenges the idea that HSC numbers are solely determined by niche availability, showing systemic and local constraints on HSC numbers regardless of niche changes.

The paper identifies semaphorin 3A as a secreted factor from revitalized MSCs that regulates HSPC proliferation in steady state and stress conditions.