Richard Janissen

The study identifies two CTCF N-terminal motifs that synergistically stall cohesin-mediated DNA loop extrusion through distinct mechanisms.

This study shows cohesin supercoils DNA during loop extrusion, influencing genome architecture through both looping and supercoiling.

The paper measures the twist induced by eukaryotic SMC proteins during DNA loop extrusion and finds all three SMC complexes induce a consistent -0.6 twist per step.

This study shows DNA supercoiling enhances ParB-DNA condensation, forming partition complexes at lower ParB concentrations than on relaxed DNA.

This study visualizes twin-supercoiled domains formed during transcription using single-molecule experiments, showing equal upstream and downstream supercoiling without requiring RNA transcript drag.