BiophysicsbioRxivPreprint
Computational Insights into How Structural Changes in the Hydrophobic Region of ALS-Linked Mutant SOD1 (G93A) Activate Fluctuations of the Electrostatic Loop: Implications for Aggregation
Kazuaki Fukushima, Kyoka Yano, Leonard M.G. Chavas, Noriko Fujiwara
This study uses molecular dynamics simulations to show how the G93A mutation in SOD1 increases electrostatic loop fluctuations, while the I35S mutation reduces these fluctuations, linking structural changes to aggregation in fALS.
DOI 10.64898/2026.11.12.766077