Pedro José Barbosa Pereira

This study reports the chemical synthesis of thrombostasin and a hepta-glutamate analogue, along with evaluation of their thrombin inhibitory and anticoagulant activity.

This paper develops supramolecular anticoagulants that can be reversed on demand using a PNA antidote, demonstrating potent in vitro and in vivo anticoagulant activity.

The paper evaluates 43 methods for predicting intrinsically disordered regions and binding regions in proteins, finding that deep learning methods outperform older physicochemical approaches but binding prediction remains challenging.