Richard J. Payne

Overexpressing rice peptide OsPSY8 lengthens roots but lowers osmotic stress survival, while knockout raises it; OsWRKY24 represses the OsPSY8 promoter and is induced by PEG.

This study reports the chemical synthesis of thrombostasin and a hepta-glutamate analogue, along with evaluation of their thrombin inhibitory and anticoagulant activity.

The paper identifies new substrates of POFUT3 and POFUT4 using structural homology searches, showing MFAP2/MFAP5 are O-fucosylated and require POFUT3 for secretion.

This study determines the cryo-EM structures of DARC bound to chemokines CCL7 and CXCL8, revealing unique binding mechanisms and the role of tyrosine sulfation and allelic variation in chemokine engagement.

The paper identifies cyclic peptides that bind RIPK3's RHIM-containing region, enabling visualization of its monomeric and functional amyloid conformations in live cells.

The paper presents analyses to assess selection dynamics in multi-round protein selection experiments, offering insights into diversity, coverage, and reproducibility.

This study investigates BRD4's nucleosomal binding affinity and shows that histone acetylation modestly enhances this interaction, with little dependence on acetylation pattern.

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

This study identifies a genetic locus affecting insulin sensitivity in mice, showing that Defa26 modulates glucose homeostasis through microbiome interactions.

This study develops pan-specific monoclonal antibodies to detect pseudaminic acids in bacteria, enabling deeper glycoproteomic analysis and improved phagocytosis of multidrug-resistant strains.

This study demonstrates that HOIL-1 can ubiquitinate non-proteinaceous substrates like saccharides in vitro, identifies a key residue for this activity, and produces ubiquitinated saccharides as potential tools.

This paper develops supramolecular anticoagulants that can be reversed on demand using a PNA antidote, demonstrating potent in vitro and in vivo anticoagulant activity.

The paper evaluates gallinamide A and its analogs against Trypanosoma cruzi, finding that intramolecular π-π stacking interactions enhance potency by improving solubility and permeability.