Daniel Ford

This study reports the chemical synthesis of thrombostasin and a hepta-glutamate analogue, along with evaluation of their thrombin inhibitory and anticoagulant activity.

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

This paper develops supramolecular anticoagulants that can be reversed on demand using a PNA antidote, demonstrating potent in vitro and in vivo anticoagulant activity.