Alexandre Giraud-Gatineau

The paper examines how host adaptation influences genome evolution and virulence in Leptospira interrogans, showing distinct genetic and regulatory changes in rodent- and cattle-associated lineages.

This study uses dual RNA-Seq to identify bacterial effectors that disrupt host cell junctions and enable Leptospira colonization by modulating calcium signaling.

This paper identifies DMEM and EMEM as better in vitro media for studying leptospiral pathogenesis compared to EMJH and HAN by mimicking host gene expression profiles.

This study identifies genetic and phenotypic traits associated with virulence in Leptospira by comparing environmental and pathogenic strains.

The paper identifies oxadiazole-based compounds that enhance anti-tuberculosis treatment by increasing host resistance through zinc poisoning of Mycobacterium tuberculosis.

The paper introduces Annotator-RNAtor for pan-species transcriptomic analysis and applies it to study adaptation in Leptospira species, finding higher katE expression in virulent P1+ strains linked to oxidative stress tolerance.