Sarah L. Londrigan

This study develops an iPSC-derived air-liquid interface platform to study AT2-macrophage interactions in homeostasis, infection, and repair, revealing their roles in antiviral immunity and epithelial repair.

This study uses CRISPR-Cas9 to enrich specific transcripts for long-read sequencing, enabling efficient and accurate isoform discovery and low abundance transcript detection.

This study shows that influenza-infected macrophages release viral ribonucleoproteins (vRNPs) that trigger inflammatory responses in uninfected cells through the RIG-I/MDA5 pathway.