Scarlet S. Shell

This study defines the interactions among mycobacterial mRNA degradation enzymes and identifies the functional roles of RNase E's intrinsically disordered regions in degradation processes.

The paper uses AI-based protein-protein interaction predictions to characterize protein function in mycobacterial pathogens, identifying key interactions and functions for previously uncharacterized proteins.

This study identifies cleavage requirements and specificities of mycobacterial RNase E using in vitro assays, showing substrate length, 5' phosphate preference, and cleavage position dependencies.

This paper identifies GplR1, a transcription factor in Mycobacterium abscessus, as a regulator of glycopeptidolipid production, colony morphology, and virulence.

This study identifies MutT4 in Mycobacterium tuberculosis as the RppH homolog, showing it forms condensates that facilitate mRNA degradation and enhance stress resistance.

This study identifies transcript properties influencing stability and stabilization in Mycolicibacterium smegmatis under different growth conditions using mRNA degradation profiling and machine learning.

The paper isolates a methoxylated flavone from Artemisia afra that shows potent anti-Mtb activity against both aerobic and hypoxic Mtb strains.

This study defines the role of RNase E in mRNA degradation in Mycolicibacterium smegmatis, showing it limits degradation of 89% of protein-coding genes and has distinct sequence preferences compared to gram-negative bacteria.