Judith V.M.G. Bovée

This paper uses machine learning to classify leiomyosarcoma based on methylation signatures, finding differences in PD-1 pathway activation and immune cell composition between tumor subtypes.

This study links immune infiltration in chordomas to increased transcriptional activity and distinct metabolic profiles, but causality remains unclear.

This paper uses single-nuclei RNA sequencing and spatial transcriptomics to characterize KPGCT, showing neoplastic cells express HMGA2::NCOR2 fusions and activate the hippo pathway, driving CSF1 production and macrophage recruitment.

This study compares immunogenic features between undifferentiated soft tissue sarcoma and myxofibrosarcoma, finding differences in T cell and macrophage infiltration and their prognostic significance.

This study analyzes the genomic changes in osteosarcoma over time using WGS, revealing increasing genomic complexity and variable evolutionary patterns.

This study profiles chordoma immunity using multimodal approaches, identifying two immune contextures and their association with T cell infiltration and clinical outcomes.