Jessica P Roelands

This study shows that elevated MPS1 causes chromosomal instability in colon cancer by converting the fibrous corona into a source of merotelic kinetochore-microtubule attachments.

The paper investigates how inflammation reprograms goblet cells into tumor-initiating cells in colon cancer using single-cell RNAseq and mutation spectrum analysis.

This study identifies immune subtypes of colorectal cancer using methylation patterns, linking them to distinct clinical outcomes and immune programs.

GRIDGENE identifies tissue compartments using transcript density in spatial transcriptomics data, enabling analysis without cell segmentation.

This study compares immunogenic features between undifferentiated soft tissue sarcoma and myxofibrosarcoma, finding differences in T cell and macrophage infiltration and their prognostic significance.

This study investigates how MUC2 expression affects immune infiltration in colorectal cancer using in vitro models and CRISPR knockout, finding that MUC2 loss increases immune infiltration only in HT-29 cells.

This study profiles chordoma immunity using multimodal approaches, identifying two immune contextures and their association with T cell infiltration and clinical outcomes.

The paper provides R scripts for analyzing and visualizing blood transcriptional module repertoires, demonstrating their application in septic patients' transcriptome data.