Thierry Voet

This study shows that SWI/SNF chromatin remodellers are critical for lineage specification in human embryos and blastoids by regulating enhancer accessibility and transcription factor binding.

This paper develops a modular click-chemistry strategy to modify CRISPR RNPs without disrupting their formation, enhancing DNA accessibility and enabling genome imaging.

This study uses single-cell and spatial multi-omics to analyze a malignant peripheral nerve sheath tumor, revealing chromosomal instability drives phenotypic diversity and spatial-temporal evolution.

LipoGrid quantifies lipidomic and transcriptomic changes across 143 gene knockouts, revealing gene-lipid relationships and compensatory feedback mechanisms.

SubCellSpace identifies and characterizes subcellular mRNA localization patterns in spatial transcriptomics data using a computational framework.

The paper identifies cis-acting genetic variants affecting enhancer function in Parkinson's Disease using multi-omics data and develops models to predict their regulatory impact.

This paper introduces MIMA, a deep learning framework for multi-omics integration and batch correction, which effectively removes batch effects and preserves biological information across modalities.

The paper uses single-cell RNA-sequencing to analyze cervical and placental tissues, identifying a novel trophoblast subtype and revealing similarities between maternal epithelial cells and placental trophoblasts.

The paper identifies mechanisms of whole-genome abnormal blastomere formation and their developmental outcomes in early embryos.

This paper benchmarks multimodal single-cell data integration methods to improve kidney reference atlas quality by identifying adaptive states and rare cell types.

This paper introduces Gtag&T-seq, a low-cost single-cell multi-omics method that reveals cell state plasticity and treatment response in melanoma subclones.

The paper uses single-cell RNA sequencing to identify five distinct mast cell subsets in the human colon, revealing layer-specific distribution and functional profiles.

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

This paper integrates multiple spatial-omics modalities in prostate cancer samples to reveal molecular heterogeneity and correlations between lipids and gene expression.

This study uses single-cell genome-and-transcriptome sequencing to analyze the impact of chromosome instability on cellular states and development in human preimplantation embryos.

The paper identifies ten genes critical for male and female sexual development in Plasmodium berghei and reveals a regulatory cascade governing gametogenesis.

The paper identifies molecularly distinct astrocyte subpopulations in the adult mouse brain and shows their spatial distribution has functional implications.

This study creates a single-cell transcriptome catalogue of the Drosophila brain across its lifespan, revealing regulatory erosion and identifying novel neuronal states linked to ageing.