Gaspare La Rocca

The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.

The paper shows AGO2 localizes to the nucleus in quiescent cells to silence mobile transposons via RNA interference.

This paper describes a method to engineer large focal amplifications in primary cells using ecDNAs, showing they promote proliferation and transformation.

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

The paper investigates the distribution of miR-21 between HMW-RISC and LMW-RISC fractions in thyroid cancer cell lines and finds miR-21 is more enriched in LMW-RISC.

This paper introduces a method to identify miRNA targets in vivo using Halo-Enhanced Ago2 Pulldown and demonstrates its application in mouse models.