Henry J. McSorley

This paper describes the structure of HpBARI2, a helminth-derived protein that trimerises to selectively inhibit membrane-bound ST2 receptor signaling by blocking IL-33 binding and preventing co-receptor recruitment.

This study investigates the evolutionary adaptation of helminth immunomodulators by analyzing the ARI family in different nematode species and their interactions with host IL-33 and heparan sulphate.

This study shows that S. aureus SplB induces asthma-like symptoms in mice, requiring proteolytic activity and adaptive immunity, suggesting a direct role of bacterial allergens in asthma.

This paper investigates the role of mast cell ST2 in Heligmosomoides polygyrus bakeri infection using transcriptomic and proteomic analysis, finding minimal impact on infection outcomes.

The paper identifies a helminth-derived CCP domain protein, HpBoRB, that binds RELMβ, a host protein with anti-helminth properties, suggesting a mechanism of immune evasion.

This study shows that respiratory viral infection primes lung epithelial cells to enhance antigen presentation, leading to improved T cell responses to subsequent antigens.

This paper shows that vaccinating against helminth IL-33-modulators can protect against infection by reversing immunosuppression and enhancing Th2 immunity.

This study shows that blocking the IL-33/ST2 signaling axis improves survival in a mouse model of SARS-CoV-2 infection without affecting viral load.

The paper shows that DNA and heparan sulphate binding prolongs the in vivo half-life of HpARI1 and HpARI2 proteins compared to HpARI3.

The paper determines the structure of HpARI bound to mouse IL-33, showing how HpARI blocks IL-33 signaling by competing with its receptor ST2.

The paper identifies three HpARI family members in H. polygyrus bakeri, showing they have distinct effects on IL-33-dependent Type 2 immune responses.