Per Uhlén

This study shows that cells decode calcium oscillation frequency through a multi-kinase network that regulates transcription via NF-κB and MYC.

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

This study develops a neoantigen-microbead platform for personalized T cell cancer vaccination and shows it effectively inhibits tumor growth in a mouse model.

The paper develops a multi-omics guided differentiation protocol to generate PD-vulnerable midbrain dopaminergic neurons, showing improved yield and functional recovery in mice.

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

This study compares gene expression in human PSCs under defined and undefined culture conditions, finding reduced variability and increased Ca2+ signaling in defined conditions.

The paper develops TRIC-DISCO, a pipeline for whole-brain 3D RNA imaging in adult mice, enabling single-cell resolution of transcriptional signatures and markers without strict RNase-free conditions.

Spatial tri-omic sequencing (DBiT ARP-seq and DBiT CTRP-seq) and CODEX imaging map chromatin, RNA, and protein dynamics across mammalian brain development and lysolecithin-induced neuroinflammation.

The paper analyzes Ca2+ signaling transcriptomes in adult mouse and developing human brains, revealing lineage-specific gene regulation and functional differences in radial glia and neuronal progenitors.

The paper uses light-sheet fluorescence microscopy to visualize and analyze the complete vasculature of mouse eyes across development and disease.

This study identifies Arg1+ microglia as a distinct subtype in female mice, showing their role in cognitive function through dendritic spine maturation and behavior.

This study introduces p-HTMI, an oligothiophene derivative that selectively detects live human glioblastoma and neural stem cells in vitro and in vivo.

This study shows that recombinant spider silk protein matrices support the differentiation of neural stem cells into functional AMPA-responsive neurons without animal or human-derived components.