Carrie Saunders

This study identifies two sequential conformational gates in HIV-1 Env that control fusion peptide release and host cell entry initiation.

The paper shows that affinity maturation enhances HIV-1 recognition by reshaping antibody encounter state pathways through germline-somatic residue synergy.

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.