Rory C. Henderson

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

This study identifies two sequential conformational gates in HIV-1 Env that control fusion peptide release and host cell entry initiation.

The paper shows that affinity maturation enhances HIV-1 recognition by reshaping antibody encounter state pathways through germline-somatic residue synergy.

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

This study visualizes the conformational changes of the HIV-1 fusion peptide during CD4-induced Env opening, showing it remains antibody accessible despite Env opening.

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.