Masakazu Toi

This paper shows BRCA2 loss causes genomic instability through ROS-dependent metabolic collapse, highlighting the role of glutathione metabolism and PARP inhibitors in cell death.

This study develops CTX-439, a CDK12/13 inhibitor, showing anti-tumor effects and resistance mechanisms, and proposes combining it with BCL-2 family inhibitors for cancer treatment.

This study shows that GABA treatment reduces estradiol-stimulated breast cancer cell growth and prevents estradiol-induced breast tumorigenesis in a mouse model.

This study shows metastasized breast cancer cells eliminate CD169+ macrophages from lymph nodes, impairing anti-cancer immunity.

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

This study shows estrogen can cause mammary ductal dysplasia in a mouse model and demonstrates that isoflavones can inhibit this effect.