Jeffrey G. McDonald

This study identifies SNX13 and SNX14 as proteins that maintain lysosome membrane integrity and prevent neurodegeneration by supporting lipid homeostasis and repair mechanisms.

The paper investigates DAF-12 receptor ligand responsiveness in plant-parasitic nematodes and finds structural diversity in ligand recognition.

This study shows Salmonella LPS enhances fatty acid uptake in the mouse intestine via CD36 and myeloid TLR4, linking microbial sensing to lipid absorption and host defense.

This study shows that the vomeronasal system decodes biological state from bile acid patterns, revealing sensitivity to rare ligands and information encoding through stimulus whitening.

This study shows that Nocturnin regulates mitochondrial NADP(H)/NAD(H) rhythms, affecting steroid rhythm amplitude and hepatic metabolism in mice.

This paper shows the gut microbiota regulates intestinal T cell development by directing vitamin A flux through a sequential pathway involving epithelial, myeloid, and T cells.

This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.

This study identifies TDCA, a microbiota-derived bile acid, as a mediator that restores immune checkpoint therapy efficacy after antibiotic-induced hyporesponsiveness by enhancing CD8+ T cell antitumor immunity.

This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.

This study identifies CLSTN3B as a driver of MASLD by promoting LD biogenesis and altering lipid partitioning between LDs and mitochondria, leading to mitochondrial dysfunction and oxidative stress.

This study identifies lipid metabolic reprogramming as a conserved mechanism conferring hypoxic and aging resilience in Arctic ground squirrels and C. elegans.

This study shows female sex hormones worsen retinal degeneration in a model, suggesting sex hormones influence disease severity.

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

This study identifies CLSTN3B as a key protein for adipocyte lipid droplet maturation by facilitating ER-LD contacts, enhancing lipid storage and metabolic health.

The paper identifies taurine-conjugated bile acids (tauro-BAs) as novel vomeronasal ligands that activate rodent accessory olfactory system neurons and vary in feces across species and gut microbiomes.

This paper identifies APMAP as an ER-localized antioxidant that maintains lipid and lipoprotein homeostasis, with loss of APMAP causing ER stress, lipid droplet accumulation, and altered lipoprotein maturation across multiple organisms.

This study investigates how the small intestinal epithelium integrates microbial and nutritional signals through transcriptional responses in mice, revealing distinct and overlapping regulatory mechanisms.

This study examines the phenotypic effects of SNX14 loss-of-function mutations in mice and zebrafish, revealing species-specific consequences despite conserved biochemical roles.