Assaf Friedler

This paper develops a biosensor using host-pathogen interaction peptides to rapidly detect Listeria monocytogenes with high selectivity and sensitivity.

This paper introduces FibrilPaints, a modular peptide system for selective amyloid binding and manipulation, showing that sequence variations affect binding affinity while allowing functional modifications.

This paper demonstrates that a peptide derived from CISD2/NAF-1 selectively targets and destroys ovarian cancer mitochondria, reducing tumor size and growth in vivo.

This paper introduces FibrilPaint peptides that selectively bind and track HttEx1Q44 amyloid fibrils, enabling monitoring of fibril growth and molecular targeting through ubiquitination.

The paper identifies site-specific phosphorylation of Ser352 as the molecular switch driving Tau R4 aggregation under acidosis conditions.

FibrilPaint1 measures Tau amyloid fibril length in fluids using fluorescence and microfluidics, enabling diagnostic and research applications in neurodegenerative diseases.

This study investigates how specific phosphorylation patterns affect the aggregation and condensation of the Tau-R4 domain using synthetic peptides.

This study quantifies how ultrasound affects fibril fragmentation in patient-derived and recombinant fibrils from neurodegenerative diseases, showing that patient-derived fibrils fragment more easily.

The paper demonstrates that FP20 recruits the ubiquitin-proteasome system to Tau amyloid fibrils, enabling their degradation and offering a strategy for targeting amyloid diseases.

This paper introduces a method for efficiently synthesizing multi-phosphorylated peptides to study their impact on signaling.