Author

Emily Lerner

Duke UniversityORCID 0000-0003-1597-8581Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:clinical cohort / trial· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alexandra M. Hoyt-MiggelbrinkiD· 2 shared Anoop P. PateliD· 2 shared Daniel S. WilkinsoniD· 2 shared Jessica Waibl PolaniaiD· 2 shared Katayoun AyasoufiiD· 2 shared Lucas P. WachsmuthiD· 2 shared Peter Edward FecciiD· 2 shared Selena LorreyiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersImmunology

Alexandra M. Hoyt-MiggelbrinkORCID

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2 papers

Recent·Most cited

ImmunologyClinical Cancer ResearchPeer-reviewedNov 21, 2025

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

Alexandra M. Hoyt-Miggelbrink, Jessica Waibl Polania, Lucas P. Wachsmuth…·Peter Edward Fecci

6 citations

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintNov 2, 2023

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

Selena Lorrey, Lucas P. Wachsmuth, John B. Finlay…·Peter Edward Fecci

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

3 citations

𝕏 PostBluesky