Author

Alexandra M. Hoyt-Miggelbrink

Duke UniversityORCID 0000-0003-1499-2269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

Katayoun AyasoufiiD· 3 shared Anoop P. PateliD· 2 shared Daniel S. WilkinsoniD· 2 shared Emily LerneriD· 2 shared Jessica Waibl PolaniaiD· 2 shared Kelly M. HotchkissiD· 2 shared Lucas P. WachsmuthiD· 2 shared Peter Edward FecciiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Katayoun AyasoufiORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 26, 2025

Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche

Delaney M. Wolf, Kelly M. Hotchkiss, Rachael Ann Reesman…·Katayoun Ayasoufi

This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.

1 citation

mouseflow cytometry

𝕏 PostBluesky

ImmunologyClinical Cancer ResearchPeer-reviewedNov 21, 2025

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

Alexandra M. Hoyt-Miggelbrink, Jessica Waibl Polania, Lucas P. Wachsmuth…·Peter Edward Fecci

6 citations

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintNov 2, 2023

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

Selena Lorrey, Lucas P. Wachsmuth, John B. Finlay…·Peter Edward Fecci

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

3 citations

mousehuman

𝕏 PostBluesky