Vadim M. Gumerov

Cache sensor domains of DUF3365/Tll0287 family bind covalent c-type heme through a CXXCH insertion; a signaling member behaves like an NO sensor, a stand-alone one like a redox protein.

The paper identifies ligand specificities of chemosensory receptors in the human gut microbiota, revealing key metabolites like lactate and formate as important signals.

The paper identifies a purine-binding motif in bacterial receptors and demonstrates its role in modulating second messenger signaling.