Rebecca Marlene Baron

The paper identifies branched-chain ketoacids (BCKAs) as antioxidants that improve survival in sepsis by neutralizing hydrogen peroxide and preventing lipid peroxidation, without affecting bacterial clearance.

The paper identifies bacterially-derived N-acetylputrescine as a marker of severe gram-negative bloodstream infections and shows that inhibiting its synthesis reduces bacterial growth and antibiotic resistance.

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

This study shows that mTORC1 activation during mechanical ventilation worsens lung injury in ARDS and that inhibiting mTORC1 can prevent ventilator-induced lung injury.