Jikui Guan

This study shows that combining ATR and ALK inhibitors improves survival in MYCN-amplified neuroblastoma mouse models lacking ALK mutations.

This study identifies ALK signaling's role in enhancing DNA damage response in neuroblastoma, showing that combined ATR/ALK inhibition leads to sustained tumor response and differentiation.

The paper demonstrates that ALKALs activate ALK/LTK family receptors and are involved in neural crest development using zebrafish and Drosophila models.