Selahattin Can Özcan

GLproxScape reconstructs spatial chromatin occupancy landscapes from genomic locus proteomics data by modeling per-region enrichments as spatial measurements.

This study identifies metabolic and signaling pathways that enable pancreatic cancer cells with centrosome amplification to survive stress, highlighting vulnerabilities for therapeutic targeting.

The paper uses proximity labeling and mass spectrometry to map NEK2 interactions across the cell cycle, revealing a NEK2-NUSAP1 degradation pathway.

This paper screens epigenetic drugs to identify Type I PRMT inhibitors that inhibit lysosomal exocytosis and enhance chemotherapy efficacy in cancer.

This study shows Nek2A unclusters extra centrosomes and induces cell death in cancer cells, but not in normal cells, through interaction with KIF2C.

This paper shows that prolonged PLK4 overexpression leads to centrosome amplification through interconnected centrosome rosette clusters (CRCs) that depend on centrosomal linker proteins.