Batuhan Mert Kalkan

This study identifies metabolic and signaling pathways that enable pancreatic cancer cells with centrosome amplification to survive stress, highlighting vulnerabilities for therapeutic targeting.

The paper uses proximity labeling and mass spectrometry to map NEK2 interactions across the cell cycle, revealing a NEK2-NUSAP1 degradation pathway.

This study shows Nek2A unclusters extra centrosomes and induces cell death in cancer cells, but not in normal cells, through interaction with KIF2C.

This paper shows that prolonged PLK4 overexpression leads to centrosome amplification through interconnected centrosome rosette clusters (CRCs) that depend on centrosomal linker proteins.

The paper develops small molecule inhibitors of MEIS1 that modulate HSC activity and show efficacy in vitro and in vivo.

This study develops CRISPR/Cas9 strategies to correct HBB gene mutations in human cells using HDR, showing longer gRNAs have higher target affinity.