Jeffrey Isaac Traylor

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

This paper uses preoperative brain mapping to predict language outcomes after glioma resection, finding that subcortical white matter resection predicts long-term deficits with high accuracy.

This study develops matched patient-derived organoids and cell lines from melanoma brain metastases to evaluate responses to targeted therapies, finding both models respond to BRAF and MEK inhibitors.