Pornparn Kongpracha

This study shows that PI3K mutations contribute to resistance to KRAS inhibitors in colorectal cancer and that combining RAS and PI3K inhibition overcomes this resistance.

This study identifies Mac1 as a therapeutic target for SARS-CoV-2 and demonstrates that AVI-4206, a small molecule inhibitor, reduces viral replication and improves survival in an animal model.

The paper shows that SV endocytosis in hippocampal neurons occurs clathrin-independent, but AP-2 mediates retrieval of specific SV proteins.

This study develops human brainstem organoids containing neural crest cells and various neuron types, validated by single-cell RNA sequencing, proteomics, and electrophysiology.