Author

Caitlin E.M. Thornton

University of BirminghamORCID 0000-0003-1787-1155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Christopher J. McCabeiD· 2 shared Hannah R. NietoiD· 2 shared Katie BrookesiD· 2 shared Kristien BoelaertiD· 2 shared Martin L. ReadiD· 2 shared Moray J. CampbelliD· 2 shared Vicki E. SmithiD· 2 shared Alice Fletcher· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Christopher J. McCabeORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 27, 2024

Dual agonism of sodium iodide symporter function in vivo

Katie Brookes, Caitlin E.M. Thornton, Ling Zha…·Christopher J. McCabe

This study identifies Cu(DDC)2-alb as a dual agonist that enhances RAI uptake in thyroid cancer by stabilizing NIS and inducing thyroid transcription factors.

DOI 10.1101/2024.02.27.582332

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 7, 2019

Pharmacologically targeting a novel pathway of sodium iodide symporter trafficking to enhance radioiodine uptake

Alice Fletcher, Martin L. Read, Caitlin E.M. Thornton…·Christopher J. McCabe

This study identifies ARF4 and VCP as regulators of NIS trafficking and shows FDA-approved VCP inhibitors enhance radioiodine uptake in thyroid cancer cells and mice.

DOI 10.1101/622241

humanproteomics

𝕏 PostBluesky