Utako Yokoyama

Ryanozole, a RyR2-selective stabilizer, prevents stress-induced arrhythmias without impairing cardiac function in CPVT mouse models.

This study finds that elevated circulating myosin-11 levels are associated with atherosclerotic cardiovascular disease risk in asymptomatic individuals and patients with ischemic heart disease.

This study identifies STC1 as a pressure-induced gene in IPAH PASMCs that suppresses proliferation and vascular remodeling through PIEZO1, suggesting STC1 as a therapeutic target.

This study identifies EP4 and fibulin-1 as key regulators of vascular intimal hyperplasia through VSMC proliferation, suggesting EP4 antagonists or fibulin-1 downregulation as potential therapeutic strategies.