EGFR-targeted affibody-polyIC polyplex kills EGFR-overexpressing cancer cells without activating the EGFR
Anne Pettikiriarachchi, Yelena Ugolev, Richard W. Birkinshaw…·Alexander Levitzki
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The University of MelbourneORCID 0000-0003-1825-0182Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Anne Pettikiriarachchi, Yelena Ugolev, Richard W. Birkinshaw…·Alexander Levitzki
Alexandra D. Gurzau, Richard W. Birkinshaw, Andrew P. Leis…·Marnie E. Blewitt
This study identifies a second DNA-binding site in SMCHD1 and shows that DNA binding stimulates its ATPase activity, revealing a mechanism for gene silencing.
Kaiming Li, Yu Q. Yap, Donia M. Moujalled…·Guillaume Lessène
This study identifies a small molecule that differentially regulates BAX and BAK apoptotic activity by modulating their interaction with VDAC2, revealing therapeutic potential for overcoming drug resistance in leukemia.
Zhengwei Yuan, Mark F. van Delft, Xiang Li…·Grant Dewson
This study identifies key residues in the BAK:VDAC2 interaction, showing that disrupting this interaction can inhibit or promote apoptosis depending on the context.