Author

Florian David

Chalmers University of TechnologyORCID 0000-0003-1831-1619Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Florian David1 paper · École Polytechnique Fédérale de Lausanne

Biology Disciplines

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Synthetic Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Christos SkrekasiD· 2 shared Jens NielseniD· 2 shared Verena SiewersiD· 2 shared Aleksej ZelezniakiD· 1 shared Azam Sheikh MuhammadiD· 1 shared Christoph S BörliniD· 1 shared Devdatt DubhashiiD· 1 shared Jan ZrimeciD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

Christos SkrekasORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintJul 16, 2023

Biosensor-Assisted Laboratory Evolution of Malonyl-CoA production in Saccharomyces cerevisiae

Raphaël Ferreira, Karl Alex Hedin, Jens Nielsen, Florian David

This study develops a CRISPR-dCas9 platform to enhance malonyl-CoA production in yeast through laboratory evolution.

DOI 10.1101/2023.07.16.549225

yeastgenetic perturbation / CRISPR

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Synthetic BiologyNature CommunicationsPeer-reviewedAug 30, 2022

Supervised generative design of regulatory DNA forgene expression control

Jan Zrimec, Xiaozhi Fu, Azam Sheikh Muhammad…·Aleksej Zelezniak

This paper introduces ExpressionGAN, a deep learning model that generates functional regulatory DNA with specified expression levels, outperforming random mutagenesis approaches.

99 citationstop 2%

DNA methylationwhole-genome sequencing

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Synthetic BiologyPLoS ONEPeer-reviewedDec 17, 2020

Does co-expression of Yarrowia lipolytica genes encoding Yas1p, Yas2p and Yas3p make a potential alkane-responsive biosensor in Saccharomyces cerevisiae?

Yasaman Dabirian, Christos Skrekas, Florian David, Verena Siewers

The paper evaluates the potential of Yarrowia lipolytica's alkane-sensing TFs as a biosensor in Saccharomyces cerevisiae but finds they do not function as expected in the new host.

2 citations

yeastexperimental assay

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