Alison Lesley Marsden

The paper introduces a computational toolkit to simulate organ-scale oxygen transport and predict tissue ischemia by analyzing vessel networks and physiological conditions.

The paper develops a patient-specific cardiac mechanics model using clinical data and evaluates its performance against simplified models, finding that truncation significantly affects results.

The paper shows that atrial peristalsis drives the transition from a bicuspid to quadricuspid valve in zebrafish through Klf2a-Snai1b signaling and shear stress alignment.

This paper develops a biomechanical framework to optimize the design of a pulsatile Fontan conduit for congenital heart defect palliation, focusing on microstructure and material properties to achieve desired hemodynamic performance.

The paper shows high shear stress induces endothelial-mesenchymal transition and pulmonary arterial hypertension by reducing ERG expression, which can be mitigated by ERG replenishment.

This study examines how bioprosthetic pulmonary valve sizing and orientation affect hemodynamics and performance using in vitro 4D-Flow MRI and imaging.

The paper develops a computational pipeline to create digital twins of cardiac electrophysiology for pediatric congenital heart disease patients using BLNMs to match clinical ECGs.