Amar Deep

This study identifies how TRIM37 prevents ectopic spindle pole formation by recognizing peptide motifs in centrobin and undergoing substrate-dependent oligomerization.

This study identifies a bacterial NLR-related protein that detects phage infection through a conserved interface, triggering programmed cell death to limit viral spread.

This study reveals that the bacterial SMC Wadjet complex uses loop extrusion to specifically recognize and cleave plasmid DNA, establishing loop extrusion as a conserved mechanism across SMC complexes.

This study shows that dimeric SMC motors switch extrusion directionality based on DNA tension, with cohesin being constitutively biased toward one-sided extrusion.

This study reveals the molecular architecture and infection-sensing mechanism of the bacterial PARIS defense system, showing how it is triggered by a phage counterdefense protein.

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

This study shows phosphorylation disrupts tau's ability to undergo phase separation and interact with chromatin, potentially contributing to nuclear dysfunction in Alzheimer's disease.