Author

Franz Sebastian Gruber

University of DundeeORCID 0000-0003-2008-8460Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:Drosophila· 1 Assay:imaging· 1

Frequent Co-Authors

Christopher L. R. BarrattiD· 2 shared Zoe C JohnstoniD· 2 shared Abhijeet KrishnaiD· 1 shared Anthony RichardsoniD· 1 shared Carl D. ModesiD· 1 shared Caroline WilsoniD· 1 shared Charlie DuclutiD· 1 shared David P. DayiD· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Christopher L. R. BarrattORCID

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3 papers

Recent·Most cited

Developmental BiologyeLifePeer-reviewedDec 20, 2023

Core PCP mutations affect short time mechanical properties but not tissue morphogenesis in the Drosophila pupal wing

Romina Piscitello-Gómez, Franz Sebastian Gruber, Abhijeet Krishna…·Suzanne Eaton

The paper investigates the role of core PCP mutations in Drosophila pupal wing morphogenesis and finds they do not affect tissue shape changes but influence fast mechanical responses.

7 citations

Drosophilaexperimental assay

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Cell BiologybioRxivPreprintSep 15, 2023

Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa

Zoe C Johnston, Franz Sebastian Gruber, Rachel Myles…·Jason R. Swedlow

This paper adapts a cell painting assay to human spermatozoa to create an image-based fingerprint for studying compound effects on sperm function and contraceptive discovery.

DOI 10.1101/2023.09.15.557919

humanimaging

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Developmental BiologyeLifePeer-reviewedJan 27, 2020

A phenotypic screening platform utilising human spermatozoa identifies new compounds with contraceptive activity

Franz Sebastian Gruber, Zoe C Johnston, Christopher L. R. Barratt, Paul D. Andrews

This study develops an automated platform to screen compounds against human sperm motility and acrosome reaction, identifying new contraceptive candidates from a large molecular library.

20 citations

humanexperimental assay

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