Claudia D. Consalvo

The paper reports cryo-EM structures of the C. elegans antiviral complex DCR-1·DRH-1·RDE-4, showing how these proteins stack and interact to cleave dsRNA.

This study reconstitutes the antiviral Dicer complex in vitro to show RDE-4 stabilizes and activates it, with distinct roles for dsRBM2 and dsRBM3 in ATP hydrolysis and dsRNA cleavage.

This study reconstructs ancient Dicer helicases to uncover how ATP hydrolysis drives dsRNA translocation and cleavage, revealing evolutionary changes in helicase function across species.

The paper investigates how C. elegans Dicer collaborates with DRH-1 and RDE-4 to cleave dsRNA, revealing their roles in antiviral defense mechanisms.