Kristen Skruber

This study identifies a geothermal amoeba that divides at 63°C, setting a new upper temperature limit for eukaryotes and challenging existing paradigms about eukaryotic thermal tolerance.

The paper uses theory and simulation to show that membrane surfaces can accelerate actin filament assembly by clustering polymerases, even at high actin concentrations.

This study uses human keratinocyte models of Hailey-Hailey disease to show that combined MEK and ROCK inhibition restores epidermal integrity, suggesting a therapeutic strategy for this genetic skin disorder.

This study identifies layilin as a regulator of Treg motility and suppressive capacity in skin, showing its role in adhesion and inflammation.

The paper shows that most actin subunits in lamellipodial networks come from membrane-associated polymerases, not directly from solution.

This study identifies a novel role for profilin 1 in regulating mitochondria function and reveals a potential pathogenic mechanism for ALS-linked PFN1 variants.

This study shows that long-term actin cytoskeleton dysregulation leads to compensatory changes in microtubules and intermediate filaments in neuronal processes, affecting transport and mimicking neurodegenerative disease features.

The paper shows that mutant SOD1 increases axonal outgrowth, dendritic branching, and actin-based structures in adult motor neurons from ALS mouse models, suggesting a potential therapeutic target.