Eric A. Vitriol

This study identifies a hyperactivating mutation in Fmnl2 causing brain and vertebrae defects in mice through a forward genetics screen.

This paper introduces MT-ID and Act-ID, proximity-labeling tools to identify microtubule and actin-interacting proteins, and discovers novel regulators like LIMCH1 and FBXO30.

The paper introduces SiR-XActin, a far-red fluorescent probe for imaging actin dynamics in live cells with minimal cytotoxicity and without genetic modifications.

This study shows that long-term actin cytoskeleton dysregulation leads to compensatory changes in microtubules and intermediate filaments in neuronal processes, affecting transport and mimicking neurodegenerative disease features.

This study identifies a novel role for profilin 1 in regulating mitochondria function and reveals a potential pathogenic mechanism for ALS-linked PFN1 variants.

The paper shows that mutant SOD1 increases axonal outgrowth, dendritic branching, and actin-based structures in adult motor neurons from ALS mouse models, suggesting a potential therapeutic target.