Johnjoe McFadden

This study identifies SerC as a critical metabolic enzyme in Mtb, showing its essential role in survival and revealing it as a potential drug target for TB therapy.

The paper creates and characterizes LH2 variants in PNSB to study energy transfer dynamics and their impact on light-harvesting efficiency and bacterial fitness.

This study quantifies carbon-nitrogen and nitrogen metabolism in mycobacteria using Bayesian multi-model-based 13C15N metabolic flux analysis, identifying glutamate as a central metabolic node.

This paper identifies the metabolic flux partitioning between the TCA cycle, glyoxylate shunt, and reversible methyl citrate cycle in Mtb as critical for its nutritional flexibility when co-metabolizing carbon substrates.

This study investigates nitrogen metabolism in intracellular Mycobacterium tuberculosis using a systems-based approach, revealing compartmentalized utilization of host-derived nitrogen sources.