VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for Mycobacterium tuberculosis Virulence
Jordan Pascoe, Jane Newcombe, Jessica Mendoza…·Dany J. V. Beste
Author
University of SurreyORCID 0000-0002-6331-2605Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Jordan Pascoe, Jane Newcombe, Jessica Mendoza…·Dany J. V. Beste
Michael James Perret, Tom A. Mendum, Daniel J. Kim…·Khushboo Borah
This study identifies SerC as a critical metabolic enzyme in Mtb, showing its essential role in survival and revealing it as a potential drug target for TB therapy.
Philippa Hollinghurst, Lam Yin Cheung, Rayne Alexander…·Kevin Maringer
This study shows that mosquito NF-κB-mediated immunity broadly suppresses arbovirus replication but has virus-specific effects, highlighting the complexity of antiviral barriers in mosquitoes.
Khushboo Borah, Tom A. Mendum, Nathaniel D. Hawkins…·Dany J. V. Beste
This paper identifies the metabolic flux partitioning between the TCA cycle, glyoxylate shunt, and reversible methyl citrate cycle in Mtb as critical for its nutritional flexibility when co-metabolizing carbon substrates.
Víctor A. López-Agudelo, Tom A. Mendum, Emma Laing…·Rigoberto Ríos‐Estepa
This study evaluates eight Mtb metabolic models to identify the best performing ones and refine them for future research.