Sandra Isabel Anjo

The paper compares the neuroprotective effects of bone marrow MSCs and iPSC-derived MSCs secretomes in a Parkinson's disease model, finding that iMSCs secretome better preserves dopaminergic neurons and activates broader protective pathways.

This study shows that physioxia-modulated UC-MSC secretome better preserves neuronal network and translation processes in an in vitro HIE model than traditional UC-MSCs.

This study shows that culturing mesenchymal stem cells under physiological stiffness and oxygen conditions increases secretion of redox and immunomodulatory proteins while reducing extracellular matrix proteins.

This paper shows that culturing MSCs on soft substrates or under low oxygen levels alters their proteome, promoting a more naive phenotype by affecting redox homeostasis, protein chaperones, and translational complexity.

This paper evaluates HMW fractionation as a complementary proteomics approach to identify serum biomarkers for neurodegenerative diseases, showing improved discrimination compared to direct serum analysis.

This study shows that Huntington's Disease leads to increased release of mitochondrial components via extracellular vesicles due to mitochondrial and lysosomal dysfunction.