Robert J. Linhardt

This study identifies sex- and region-specific astrocyte molecular changes in response to chronic ethanol, highlighting extracellular matrix and glycosaminoglycan remodeling as key factors in ethanol-related neuroplasticity.

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

The paper shows that ethanol inhibits astrocyte translation of Chpf2 and Chsy1, reducing CS-GAGs and increasing dendritic arborization in hippocampal neurons.

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.