Ryann M. Perez

This paper introduces hint token learning to improve protein language models on mutational datasets through three case studies, showing better performance than traditional fine-tuning.

The paper uses structural and chemical biology methods to show EX-6 binds selectively to α-synuclein fibrils in MSA tissue, with a 10-fold preference over PD tissue.

This study investigates how thioamide substitutions in SpyTag affect ligation kinetics with SpyCatcher, showing both faster and slower complex formation depending on substitution position.

The paper determines the structure of the LexA-RecA* complex, revealing a lock-and-key mechanism that triggers SOS response gene induction by enabling LexA cleavage.